Your browser does not support JavaScript!

Interleukin-6 (IL-6)

Lab Test
  • Test Cost:  

This test is used to help evaluate a person with a condition associated with infection or inflammation such as lupus, rheumatoid arthritis, COVID-19, etc. Interleukin acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 can be elevated with inflammation, infection, autoimmune disorders, cardiovascular diseases, and some leukemias.

It can also be used to assist in early detection of respiratory failure, ie. identifying severe inflammatory response in patients to aid in determining the risk of intubation with mechanical ventilation. This is especially true in the case of COVID-19.

Interleukin-6 (IL-6) has important roles in both innate and adaptive immunity. IL-6 can be produced by a variety of different cell types, including macrophages, endothelial cells, and T cells. This production can be initiated in response to microbial invasion or other cytokines, such as tumor necrosis factor (TNF). As part of the innate immune system, IL-6 acts on hepatocytes to induce expression of C-reactive protein (CRP), fibrinogen, and serum amyloid A, also known as the acute phase response. Within the adaptive immune response, IL-6 plays a key role in activing antibodyproducing B cells to proliferate, leading to an enhanced antibody response.

Concentrations of IL-6 are elevated in patients with infection, sepsis, and septicemia. In addition, IL-6 concentrations appear to correlate with severity of sepsis, as defined by clinical and laboratory parameters. Elevations in IL-6 also appear to be associated with more localized infections, such as prosthetic joint infections (PJI). A recent meta-analysis demonstrated that IL-6 had improved diagnostic accuracy for PJI compared to CRP, erythrocyte sedimentation rate (ESR), and white blood cell counts. IL-6 is also elevated in numerous chronic inflammatory disorders, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and inflammatory bowel disease (IBD). There is evidence that IL-6 is involved in the pathogenesis of certain chronic inflammatory disorders.

Used for:

  • COVID-19
  • Autoimmune disorders
  • Leukemia
  • Sepsis
  • Diabetes
  • Cardiovascular diseases
  • Rheumatoid arthritis
  • lupus


Next Day 6 PM


No special preparation required


Pathology / Immunoassay


Reliable and Trustworthy

All tests and packages are fulfilled by verified diagnostic centers and laboratories. These are reputed labs with trusted quality, reliable reports and proper testing facility, have conducted 1000's of tests.

Extensive test coverage

With over 700 tests ranging from Lab tests to Radiology tests, and Health Checkups, we cover curative as well as preventive health tests, ideal for identifying health risk well in advance and taking preventive steps towards them.

Simple and Convenient

The process is made simple and convenient from booking the test online, to receiving your reports digitally. We have you covered. Qualified and certified professionals will collect your samples and conduct the scans.

Digital Reports

A detailed online report will be shared with you on mobile app or email, within 24 to 48 hours of sample collection, depending on the test.

A detailed online report will be shared with you on mobile app or email, within 24 to 48 hours of sample collection, depending on the test.