The Interleukin 6 or (IL-6) test is used to help evaluate a person with a condition associated with infection or inflammation such as lupus, rheumatoid arthritis, COVID-19, etc. Interleukin acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 can be elevated with inflammation, infection, autoimmune disorders, cardiovascular diseases, and some leukemias.
It can also be used to assist in early detection of respiratory failure, ie. identifying severe inflammatory response in patients to aid in determining the risk of intubation with mechanical ventilation. This is especially true in the case of COVID-19, infection caused by the SARS COV2 2019 coronavirus.
Interleukin-6 (IL-6) has important roles in both innate and adaptive immunity. IL-6 can be produced by a variety of different cell types, including macrophages, endothelial cells, and T cells. This production can be initiated in response to microbial invasion or other cytokines, such as tumor necrosis factor (TNF). As part of the innate immune system, IL-6 acts on hepatocytes to induce expression of C-reactive protein (CRP), fibrinogen, and serum amyloid A, also known as the acute phase response. Within the adaptive immune response, IL-6 plays a key role in activing antibody producing B cells to proliferate, leading to an enhanced antibody response.
Elevated IL-6 levels have been reported to be associated with a variety of diseases, including autoimmune diseases such as arthritis and Castleman's disease, mesangial proliferative glomerulonephritis, psoriasis, inflammatory bowel disease, and malignancies such as plasmacytomas, myelomas , lymphomas and leukemias, and ovarian cancers.
Elevated levels are also observed in a variety of inflammatory processes, including infections and collagen vascular diseases. Elevations in IL-6 also appear to be associated with more localized infections, such as prosthetic joint infections (PJI).
IL-6 is also elevated in numerous chronic inflammatory disorders, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and inflammatory bowel disease (IBD). There is evidence that IL-6 is involved in the pathogenesis of certain chronic inflammatory disorders.
- Autoimmune disorders
- Cardiovascular diseases
- Rheumatoid arthritis
Next Day 6 PM
No special preparation required
Pathology / Immunoassay
Dr Mittal's Diagnostic Centre
- ₹ 3500
Neuberg Anand Reference Laboratory
Shivaji Nagar, Bengaluru
- ₹ 2950
Neuberg Supratech Micropath Laboratory
Parimal Garden, Ahmedabad
- ₹ 2950
Neuberg AG Diagnostics
Deccan Gymkhana, Pune
- ₹ 2950
- ₹ 3000
Neuberg Ehrlich Laboratory
- ₹ 2950
Neuberg Diagnostics, Hyderabad
- ₹ 2950
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With over 750 tests ranging from Lab tests to Radiology tests, and Health Checkups, we cover curative as well as preventive health tests, ideal for identifying health risk well in advance and taking preventive steps towards them.
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A detailed online report will be shared with you on mobile app or email.
A detailed online report will be shared with you on mobile app or email, within 24 to 48 hours of sample collection, depending on the test.